Deaths linked to Iran’s ongoing protests have risen to more than 500, according to a human rights group, as tensions sharply escalated between Tehran and Washington over the government’s response to demonstrators.

The rights group said hundreds of people have been killed since unrest erupted over worsening economic conditions, soaring inflation and political repression. Thousands more are believed to have been injured or detained as security forces intensify crackdowns across major cities and provincial towns. Iranian authorities have not released official casualty figures.

The protests have drawn strong condemnation from the United States, with President Donald Trump warning Iran against violent repression of civilians. In response, Tehran issued a stark warning, threatening to target U.S. military bases in the region and Israel if Washington follows through on any military action against Iran.

Iranian officials accused the United States and its allies of inciting unrest and interfering in the country’s internal affairs. State media portrayed the protests as foreign backed, while rights organisations and opposition groups say the demonstrations reflect widespread domestic anger over economic hardship and political restrictions.

The rising death toll and escalating rhetoric have heightened fears of a broader regional confrontation, particularly as Iran’s allies and adversaries remain on high alert. Analysts warn that further violence against protesters could deepen Iran’s international isolation and increase the risk of direct conflict with the United States and Israel.

Calls have intensified from international organisations for an independent investigation into the deaths and for Iranian authorities to restore internet access, release detainees, and respect the right to peaceful protest.